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KMID : 1237720230560040463
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Anatomy & Cell Biology
2023 Volume.56 No. 4 p.463 ~ p.468
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Histology and immunohistochemistry of the human carotid sinus nerve
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Davin Bryant
Erin McCormack
Juan J. Cardona
Arada Chaiyamoon
Devendra Shekhawat
Francisco Reina
Ana Carrera
Joe Iwanaga
Aaron S. Dumont
R. Shane Tubbs
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Abstract
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The carotid sinus nerve (CSN) is well known as mediating baroref lexes. However, studies of its detailed histologicalanalysis are scant in the literature. Therefore, the current anatomical study sought to better elucidate the microanatomy of theCSN. Ten fresh frozen adult cadavers underwent dissection of the CSN. Then, it was harvested and submitted for histologicaland immunohistochemical staining. Specimens were all shown to be nerve fibers on histology and immunohistochemistry.
We identified tyrosine hydroxylase positive fibers in all CSN specimens. These fibers were always found to be within theCSN and not on its surface i.e., epineurium. Based on our findings, the majority of fibers contained in the CSN are tyrosinepositive in nature. Further studies are necessary to understand the true function of this autonomic nerve fibers.
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KEYWORD
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Carotid sinus nerve, Histology, Immunohistochemistry, Nerve stimulation, Anatomy
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